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A Short Guide to Brain ImagingThe Neuroscience of Human Cognition$
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Richard E. Passingham and James B. Rowe

Print publication date: 2015

Print ISBN-13: 9780198709138

Published to Oxford Scholarship Online: November 2015

DOI: 10.1093/acprof:oso/9780198709138.001.0001

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Anatomy

Anatomy

Chapter:
(p.55) Chapter 4 Anatomy
Source:
A Short Guide to Brain Imaging
Author(s):

Richard E. Passingham

James B. Rowe

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198709138.003.0004

Once the statistical analysis has been performed, the location of the activations has to be established. The importance of this step lies in the fact that the location provides a link to the anatomical connections, since it is these that constrain the functions of the area. Each cortical area has a unique overall pattern of extrinsic connections, and it is this connectional fingerprint that provides the anatomical basis for functional localization. Thus, it is critical that an activation is assigned to the correct area, and that the localization is not described in terms of a general region, if within that region there are subareas with different connections. One can account for the function in terms of the anatomical connections. The identification of the correct cytoarchitectonic area usually depends on the warping of the image so that it fits a standardized template and the use of a probabilistic atlas to identify the most likely area for the activation.

Keywords:   anatomical fingerprint, cytoarchitectonic maps, diffusion weighted imaging, comparative anatomy, Talairach coordinates, MNI template, automatic labeling, JuBrain probability atlas

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