Jump to ContentJump to Main Navigation
A Short Guide to Brain ImagingThe Neuroscience of Human Cognition$
Users without a subscription are not able to see the full content.

Richard E. Passingham and James B. Rowe

Print publication date: 2015

Print ISBN-13: 9780198709138

Published to Oxford Scholarship Online: November 2015

DOI: 10.1093/acprof:oso/9780198709138.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2020. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 30 May 2020

Experimental methods

Experimental methods

Chapter:
(p.33) Chapter 3 Experimental methods
Source:
A Short Guide to Brain Imaging
Author(s):

Richard E. Passingham

James B. Rowe

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198709138.003.0003

Having recorded a signal, it is necessary to interpret its functional significance. The way in which this is done is to relate the signal to a psychological condition. As in other branches of science, an experimental condition is contrasted with a control condition. The interpretation is clearest when these differ in just one respect, though this can be difficult to achieve. Standard statistics are used to evaluate the significance of the difference. However, the analysis of imaging data can be onerous and many methods have been developed to avoid false-positive and false-negative results. These include robust correction for the number of statistical comparisons that are made, as the image is made up of thousands of voxels across many regions. Researchers also use targeted region-of-interest analysis; in this case the region must be specified beforehand. One must also study enough subjects: if small groups are used, the study may be underpowered.

Keywords:   control conditions, subtraction technique, false positive, false negative, type I error, type II error, replication, number of subjects

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .