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Models of Cellular Regulation$
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Baltazar Aguda, Avner Friedman, and Visiting Associate Professor, The Ohio State University

Print publication date: 2008

Print ISBN-13: 9780198570912

Published to Oxford Scholarship Online: September 2008

DOI: 10.1093/acprof:oso/9780198570912.001.0001

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Cell death

Cell death

(p.108) 8 Cell death
Models of Cellular Regulation

Baltazar D. Aguda

Avner Friedman

Oxford University Press

Apoptosis or programmed cell death is the mechanism that cells employ to eliminate cells with irreparably damaged DNA. Abnormalities in the regulation of apoptosis have been implicated in the origins of various human diseases. This chapter discusses the biological manifestations of apoptosis and gives an overview of the regulatory biochemical pathways. These pathways are classified as either intrinsic or extrinsic — the former being mediated by the mitochondria, and the latter by so-called death ligands. Kinetic models of these pathways are also presented. Exercises are provided at the end of the chapter.

Keywords:   apoptosis, caspase pathways, caspase-3 activation, caspase-8 activation

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