Jump to ContentJump to Main Navigation
Models of Cellular Regulation$
Users without a subscription are not able to see the full content.

Baltazar Aguda, Avner Friedman, and Visiting Associate Professor, The Ohio State University

Print publication date: 2008

Print ISBN-13: 9780198570912

Published to Oxford Scholarship Online: September 2008

DOI: 10.1093/acprof:oso/9780198570912.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2019. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a monograph in OSO for personal use (for details see www.oxfordscholarship.com/page/privacy-policy).date: 24 June 2019

Cell-cycle control

Cell-cycle control

Chapter:
(p.96) 7 Cell-cycle control
Source:
Models of Cellular Regulation
Author(s):

Baltazar D. Aguda

Avner Friedman

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198570912.003.0007

Signalling pathways control the cell-cycle engine by regulating transitions between phases in the cell cycle. These are transitions where putative decisions are made such as initiating DNA replication (entry into S phase) or segregating duplicated chromosomes (entry into M phase). The mechanisms for regulating these transitions involve the so-called cell-cycle checkpoints. This chapter discusses the modelling of a G1 checkpoint called the restriction point in mammalian cells — a checkpoint where a cell's commitment to DNA replication is made. A G2 checkpoint that prevents cell-cycle progression into mitosis when, for example, DNA damage is not repaired is also discussed. There are various exercises at the end of the chapter.

Keywords:   cell-cycle checkpoints, restriction point, G1-S regulatory network, G2 DNA damage checkpoint, mitotic spindle checkpoint

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .