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Models of Cellular Regulation$
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Baltazar Aguda, Avner Friedman, and Visiting Associate Professor, The Ohio State University

Print publication date: 2008

Print ISBN-13: 9780198570912

Published to Oxford Scholarship Online: September 2008

DOI: 10.1093/acprof:oso/9780198570912.001.0001

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Cell-cycle control

Cell-cycle control

(p.96) 7 Cell-cycle control
Models of Cellular Regulation

Baltazar D. Aguda

Avner Friedman

Oxford University Press

Signalling pathways control the cell-cycle engine by regulating transitions between phases in the cell cycle. These are transitions where putative decisions are made such as initiating DNA replication (entry into S phase) or segregating duplicated chromosomes (entry into M phase). The mechanisms for regulating these transitions involve the so-called cell-cycle checkpoints. This chapter discusses the modelling of a G1 checkpoint called the restriction point in mammalian cells — a checkpoint where a cell's commitment to DNA replication is made. A G2 checkpoint that prevents cell-cycle progression into mitosis when, for example, DNA damage is not repaired is also discussed. There are various exercises at the end of the chapter.

Keywords:   cell-cycle checkpoints, restriction point, G1-S regulatory network, G2 DNA damage checkpoint, mitotic spindle checkpoint

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