Signalling pathways control the cell-cycle engine by regulating transitions between phases in the cell cycle. These are transitions where putative decisions are made such as initiating DNA replication (entry into S phase) or segregating duplicated chromosomes (entry into M phase). The mechanisms for regulating these transitions involve the so-called cell-cycle checkpoints. This chapter discusses the modelling of a G1 checkpoint called the restriction point in mammalian cells — a checkpoint where a cell's commitment to DNA replication is made. A G2 checkpoint that prevents cell-cycle progression into mitosis when, for example, DNA damage is not repaired is also discussed. There are various exercises at the end of the chapter.
Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.
If you think you should have access to this title, please contact your librarian.