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Models of Cellular Regulation$
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Baltazar Aguda, Avner Friedman, and Visiting Associate Professor, The Ohio State University

Print publication date: 2008

Print ISBN-13: 9780198570912

Published to Oxford Scholarship Online: September 2008

DOI: 10.1093/acprof:oso/9780198570912.001.0001

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Control of DNA replication in a prokaryote

Control of DNA replication in a prokaryote

Chapter:
(p.65) 5 Control of DNA replication in a prokaryote
Source:
Models of Cellular Regulation
Author(s):

Baltazar D. Aguda

Avner Friedman

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198570912.003.0005

A cell-division cycle, or cell cycle, is a combination of growth to double the amounts of cellular components, and division of these components between two daughter cells. This chapter discusses the cell cycle of Escherichia coli, a common bacterium that thrives in the guts of humans and other animals. Topics covered include coordinating growth and DNA replication, the oriC and the initiation of DNA replication, the initiation-titration-activation model of replication initiation, model dynamics, and robustness of initiation control. Exercises are given at the end of the chapter.

Keywords:   cell cycle, Escherichia coli, DNA replication, growth, oriC, initiation-titration-activation model

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