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Models of Cellular Regulation$
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Baltazar Aguda, Avner Friedman, and Visiting Associate Professor, The Ohio State University

Print publication date: 2008

Print ISBN-13: 9780198570912

Published to Oxford Scholarship Online: September 2008

DOI: 10.1093/acprof:oso/9780198570912.001.0001

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Gene-regulatory networks: from DNA to metabolites and back

Gene-regulatory networks: from DNA to metabolites and back

(p.44) 4 Gene-regulatory networks: from DNA to metabolites and back
Models of Cellular Regulation

Baltazar D. Aguda

Avner Friedman

Oxford University Press

DNA has at least three functions essential to life: (i) its chemistry provides a mechanism for replicating genes (via the Watson–Crick base pairing); (ii) in its long strands are nucleotide sequences containing information for producing proteins (using the universal genetic code); and (iii) DNA provides instructions on how a cell would respond or adapt to its environment for growth and survival. This chapter illustrates the third function using specific examples of gene-regulatory networks (GRNs). Topics discussed include the genome structure of Escherichia coli, the Trp operon, a model of the Trp operon, roles of the negative feedbacks in the Trp operon, the lac operon, experimental evidence and modelling of bistable behavior of the lac operon, a reduced model derived from the detailed lac operon network, and complexity of the global transcriptional network. Exercises are provided at the end of the chapter.

Keywords:   Escherichia coli, gene-regulatory networks, Trp operon, lac operon, bistable behavior, reduced model

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