Jump to ContentJump to Main Navigation
Models of Cellular Regulation$
Users without a subscription are not able to see the full content.

Baltazar Aguda, Avner Friedman, and Visiting Associate Professor, The Ohio State University

Print publication date: 2008

Print ISBN-13: 9780198570912

Published to Oxford Scholarship Online: September 2008

DOI: 10.1093/acprof:oso/9780198570912.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2019. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 24 August 2019

Multiscale modelling of cancer

Multiscale modelling of cancer

(p.155) 11 Multiscale modelling of cancer
Models of Cellular Regulation

Baltazar D. Aguda

Avner Friedman

Oxford University Press

The development of cancer involves various temporal and spatial scales, as well as multiple levels of molecular and biological organization — from genes to cells, to tissue, and to the organism. This chapter begins with a brief summary of the hallmarks of cancer, followed by a discussion of modelling tumor spheroid growth (the typical model system for avascular tumors) and a model of colorectal cancer (a vascularized tumor). These two cancer models are hybrids of discrete and continuous dynamical models illustrating how the subcellular, cellular, cell population, and tissue dynamics are interfaced. Continuum models that focus on the growth of the tumor boundary and treat the cell population as a continuous fluid are discussed.

Keywords:   tumor growth, colorectal cancer, cancer cells, continuum models

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .