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Models of Cellular Regulation$
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Baltazar Aguda, Avner Friedman, and Visiting Associate Professor, The Ohio State University

Print publication date: 2008

Print ISBN-13: 9780198570912

Published to Oxford Scholarship Online: September 2008

DOI: 10.1093/acprof:oso/9780198570912.001.0001

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Multiscale modelling of cancer

Multiscale modelling of cancer

Chapter:
(p.155) 11 Multiscale modelling of cancer
Source:
Models of Cellular Regulation
Author(s):

Baltazar D. Aguda

Avner Friedman

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198570912.003.0011

The development of cancer involves various temporal and spatial scales, as well as multiple levels of molecular and biological organization — from genes to cells, to tissue, and to the organism. This chapter begins with a brief summary of the hallmarks of cancer, followed by a discussion of modelling tumor spheroid growth (the typical model system for avascular tumors) and a model of colorectal cancer (a vascularized tumor). These two cancer models are hybrids of discrete and continuous dynamical models illustrating how the subcellular, cellular, cell population, and tissue dynamics are interfaced. Continuum models that focus on the growth of the tumor boundary and treat the cell population as a continuous fluid are discussed.

Keywords:   tumor growth, colorectal cancer, cancer cells, continuum models

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