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Models of Cellular Regulation$
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Baltazar Aguda, Avner Friedman, and Visiting Associate Professor, The Ohio State University

Print publication date: 2008

Print ISBN-13: 9780198570912

Published to Oxford Scholarship Online: September 2008

DOI: 10.1093/acprof:oso/9780198570912.001.0001

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Cell aging and renewal

Cell aging and renewal

Chapter:
(p.139) 10 Cell aging and renewal
Source:
Models of Cellular Regulation
Author(s):

Baltazar D. Aguda

Avner Friedman

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198570912.003.0010

Cellular aging, commonly referred to as cellular senescence, is thought to be a ‘programmed’ cell fate in a similar sense that apoptosis is somehow programmed to happen to certain cells during development. A specific kind of aging called replicative senescence is characterized by a cell's permanent exit from the cell cycle after undergoing a certain number of divisions. One of the known causes of replicative senescence is telomere shortening after each division. Telomeres are the ends of linear eukaryotic chromosomes. This chapter discusses a model involving replicative senescence of cells lining the walls of blood vessels. Both a probabilistic model tracking individual cells and a deterministic model of the cell population dynamics are illustrated. Exercises are given at the end of the chapter.

Keywords:   cellular senescence, telomeres, aging, stem cell division, Roeder–Loeffler model, probabilities model, continuum model

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