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Supportive Care in Heart Failure$
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James Beattie and Sarah Goodlin

Print publication date: 2008

Print ISBN-13: 9780198570288

Published to Oxford Scholarship Online: November 2011

DOI: 10.1093/acprof:oso/9780198570288.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2020. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 17 January 2020

Cardiac Cachexia

Cardiac Cachexia

Chapter:
(p.245) Chapter 13 Cardiac Cachexia
Source:
Supportive Care in Heart Failure
Author(s):

Mitja Lainscak

Anja Sandek

Anker D. Stefan

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198570288.003.0013

This chapter concentrates on the pathophysiology of cardiac cachexia. It also discusses the possible clinical implications, and outlines the potential future development of therapeutic strategies. In particular, it explores the epidemiology and aetiology of cardiac cachexia. It then evaluates the alterations of body composition and the pathogenesis of cardiac cachexia. The therapeutic options include pharmacological treatment, nutritional support, and physical training. With improved knowledge of the underlying pathophysiology, a number of emerging treatment strategies for prevention and treatment are being developed and tested. Although no specific treatment is currently available, several approaches with the use of neurohormonal drugs, nutritional support, ghrelin, and physical training appear to show potential benefits and the results of ongoing clinical trials in cardiac cachexia are awaited.

Keywords:   cardiac cachexia, pathophysiology, epidemiology, aetiology, pathogenesis, pharmacological treatment, nutritional support, physical training

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