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Computational Molecular Evolution$
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Ziheng Yang

Print publication date: 2006

Print ISBN-13: 9780198567028

Published to Oxford Scholarship Online: April 2010

DOI: 10.1093/acprof:oso/9780198567028.001.0001

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Models of nucleotide substitution

Models of nucleotide substitution

Chapter:
(p.3) 1 Models of nucleotide substitution
Source:
Computational Molecular Evolution
Author(s):

ZIHENG YANG

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198567028.003.0001

This chapter discusses models of nucleotide substitution and calculation of the distance between a pair of sequences. It introduces the theory of Markov chains and the maximum likelihood method, which are used extensively later in the book. Exercises are provided at the end of the chapter.

Keywords:   nucleotide substitution, Markov chains, substitution models, distance estimation

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