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The Orbitofrontal Cortex$
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David Zald and Scott Rauch

Print publication date: 2006

Print ISBN-13: 9780198565741

Published to Oxford Scholarship Online: February 2010

DOI: 10.1093/acprof:oso/9780198565741.001.0001

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Effect of orbitofrontal lesions on mood and aggression

Effect of orbitofrontal lesions on mood and aggression

(p.579) Chapter 22 Effect of orbitofrontal lesions on mood and aggression
The Orbitofrontal Cortex

Pamela Blake

Jordan Grafman

Oxford University Press

This chapter reviews the effects of lesions in the orbitofrontal cortex (OFC) on mood states and aggressive behavior. Particular attention is paid to studies of patients with traumatic brain injury, although data from patients with stroke or degenerative disorders are also presented. Lesions of the OFC have been observed to cause disinhibited, impulsive states that result in an increase in impulsive aggression. Problems with reduced empathy and social processing may further contribute to the clinical picture. OFC lesions are not as closely associated with depression as are dorsolateral lesions. The current literature on the effects of OFC lesions in the development of anxiety appear contradictory, with some studies showing increased and others showed decreased anxiety symptoms. Methodological issues that hinder interpretation of the effects OFC lesions on personality and mood are discussed.

Keywords:   anxiety, mood, affect, impulsivity, disinhibited, aggression, neuropsychology, traumatic brain injury, depression

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