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The Orbitofrontal Cortex$
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David Zald and Scott Rauch

Print publication date: 2006

Print ISBN-13: 9780198565741

Published to Oxford Scholarship Online: February 2010

DOI: 10.1093/acprof:oso/9780198565741.001.0001

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Neuropsychological assessment of the orbitofrontal cortex

Neuropsychological assessment of the orbitofrontal cortex

(p.449) Chapter 18 Neuropsychological assessment of the orbitofrontal cortex
The Orbitofrontal Cortex

David H. Zald

Oxford University Press

This chapter reviews the neuropsychological assessment of orbitofrontal functions. It starts by describing the major categories of neurological disorders that result in lesions of the orbitofrontal cortex (OFC). Traditional neuropsychological test batteries are generally insensitive to OFC dysfunction. A number of experimental tasks have been proposed as tests of OFC functions. These include objection alternation and object reversal learning tasks, gambling tasks, go/nogo tasks, olfactory recognition, theory of mind and social processing measures, and self- or family-rating scales of the patient's behavior. The sensitivity and specificity of these measures are discussed, with a particular emphasis on issues of functional localization. The chapter concludes with a description of rehabilitation programs aimed at addressing problems associated with OFC dysfunction.

Keywords:   neuropsychology, human, decision making, frontotemporal dementia, cognition, learning

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