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The Orbitofrontal Cortex$
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David Zald and Scott Rauch

Print publication date: 2006

Print ISBN-13: 9780198565741

Published to Oxford Scholarship Online: February 2010

DOI: 10.1093/acprof:oso/9780198565741.001.0001

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Technical considerations for BOLD fMRI of the orbitofrontal cortex

Technical considerations for BOLD fMRI of the orbitofrontal cortex

(p.423) Chapter 17 Technical considerations for BOLD fMRI of the orbitofrontal cortex
The Orbitofrontal Cortex

V. Andrew Stenger

Oxford University Press

Neuroimaging plays a major role in furthering our understanding of the orbitofrontal cortex (OFC). This chapter presents some of the technical challenges, limitations, and potential solutions with regard to using Magnetic Resonance Imaging (MRI) to study the OFC. The proximity of the OFC to the sinus results in signal loss and distortion due to inhomogeneity in magnetic susceptibility. Several techniques have proven useful in reducing signal loss and distortion including shorter echo times, thinner slice acquisitions, shimming, post-processing distortion correction using field maps, reduced data acquisition methods, parallel imaging, use of rapid acquisition trajectories including reverse spiral and spiral in-out sequences, gradient compensation, and tailored radiofrequency pulses. The advantages and disadvantages of each of these imaging techniques are discussed.

Keywords:   magnetic resonance imaging, MRI, neuroimaging, functional magnetic resonance imaging, fMRI, sequence, susceptibility artifact

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