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Cephalopod NeurobiologyNeuroscience Studies in Squid, Octopus and Cuttlefish$
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N. Joan Abbott, Roddy Williamson, and Linda Maddock

Print publication date: 1995

Print ISBN-13: 9780198547907

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780198547907.001.0001

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Resting And Active K+ Channels In The Squid Axon Membrane

Resting And Active K+ Channels In The Squid Axon Membrane

Chapter:
(p.73) 5 Resting And Active K+ Channels In The Squid Axon Membrane
Source:
Cephalopod Neurobiology
Author(s):

Isao Inoue

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198547907.003.0050

This chapter shows that the potassium conductance g K of the membrane of the squid Sepioteuthis lessoniana can be separated into two components using a pharmacological tool, cytochalasin B. The delayed rectifier of the squid axon membrane was the first K+ channel to be studied extensively, and its time- and voltage-dependent characteristics and pharmacological properties were the first to be described. This channel was considered to be involved in the generation of both spike and resting potentials However, since the introduction of the patch-clamp technique (Neher and Sakmann), many different types of K+ channels have been identified in a range of cell types, and it is now clear that many of these channels are specialized for particular cell functions. This has led us to the idea that the delayed rectifier K+ channel which is responsible for the highly sophisticated function of excitable cells may be separate from the K+ channel responsible for the generation of the resting potential, a much more widespread cellular phenomenon. This idea agrees with observations of multiple types of K+ channels in the squid axon membrane obtained with patch clamp. The results from the experiments in the chapter indicate that a certain type of K+ channel might exist in the living cells more generally, and may play a role in generation of the steady-state membrane potential and conductance.

Keywords:   Sepioteuthis lessoniana, cytochalasin, K+ channels, membrane potential, patch-clamp technique, steady-state membrane

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