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Cephalopod NeurobiologyNeuroscience Studies in Squid, Octopus and Cuttlefish$
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N. Joan Abbott, Roddy Williamson, and Linda Maddock

Print publication date: 1995

Print ISBN-13: 9780198547907

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780198547907.001.0001

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Control of the spatial distribution of sodium channels in the squid giant axon and its cell bodies

Control of the spatial distribution of sodium channels in the squid giant axon and its cell bodies

Chapter:
(p.173) 13 Control of the spatial distribution of sodium channels in the squid giant axon and its cell bodies
Source:
Cephalopod Neurobiology
Author(s):

W. F. Gilly

M. T. Lucero

M. Perri

J. Rosenthal

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198547907.003.0116

This chapter summarizes the progress in developing a model system for studying the control of neuronal Na channel distribution based on the squid giant axon and its cell bodies located in the giant fibre lobe (GFL) of the stellate ganglion. Patch clamp methods have been employed to test the functional integrity of Na channels in GFL neurones maintained in primary culture, and to map the spatial distribution in cell bodies and axons. GFL neurones in vitro establish and maintain a strongly polarized Na channel distribution similar to that displayed by the system in vivo. Several manipulations that disrupt this cellular polarity, including a novel effect of the glycosylation inhibitor tunicamycin, have been identified. This drug appears to selectively inhibit high-level expression of Na channels in axonal membrane. Specificity of neuronal function at the cellular level is largely dictated by the precise spatial distribution of membrane receptors and channels. In general, the functional properties of many channels and receptors have been well studied, and in some cases their spatial distributions have been carefully mapped. Although this information is vital to understanding nerve cell function, there is still a need to learn much more about the cell biological dynamics that control both the properties and the spatial distributions of these important membrane proteins. All neurones are functionally and morphologically polarized, and the number of cellular control elements is large.

Keywords:   neuronal sodium channel, patch clamp method, cellular polarity, giant fibre lobe, squid giant axon, tunicamycin

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