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Dyspnoea in Advanced DiseaseA guide to clinical management$
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Sara Booth and Deborah Dudgeon

Print publication date: 2005

Print ISBN-13: 9780198530039

Published to Oxford Scholarship Online: November 2011

DOI: 10.1093/acprof:oso/9780198530039.001.0001

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Pharmacological approaches to breathlessness

Pharmacological approaches to breathlessness

Chapter:
(p.237) 13 Pharmacological approaches to breathlessness
Source:
Dyspnoea in Advanced Disease
Author(s):

David C. Currow

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198530039.003.0013

This chapter discusses pharmacological strategies to alleviate dyspnoea or breathlessness in patients with advanced disease. Although significant improvements have been made in the administration of pharmacological approaches in terminally ill patients suffering from dyspnoea, careful considerations should be made. In easing symptomatic breathlessness, considerations on the validity and generalizability of pharmacotherapy should be discussed and considered. This is because the palliative population is composed of heterogeneous people with various clinical situations, breathlessness problems, and responses to therapy. The main concern of the chapter is breathlessness that is refractory. Discussed in it are: the clinical data and functions of opioids in managing dyspnoea; the functions of other opioids and other medications such as indomethacin, inhaled local anaesthetics, theophylline, and buspirone; and other clinical causes of dyspnoea.

Keywords:   pharmacological strategies, pharmacological approaches, symptomatic breathlessness, pharmacotherapy, opioids, indomethacin, inhaled local anaesthetics, theophylline, buspirone

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