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Palliative Care Consultations in Haemato-oncology$
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Sara Booth, Eduardo Bruera, and Jenny Craig

Print publication date: 2003

Print ISBN-13: 9780198528081

Published to Oxford Scholarship Online: November 2011

DOI: 10.1093/acprof:oso/9780198528081.001.0001

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Myelodysplastic syndromes

Myelodysplastic syndromes

Chapter:
(p.43) Chapter 4 Myelodysplastic syndromes
Source:
Palliative Care Consultations in Haemato-oncology
Author(s):

Ghulam Mufti

Kavita Raj

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198528081.003.0004

This chapter discusses myelodysplastic syndromes (MDS), which are a spectrum of pre-leukaemic disorders that manifest in the elderly and can have a prolonged course. Patients afflicted with MDS require regular monitoring for evidence of disease progression, infections, and cytopenias that may be alleviated through proper treatment. Decision and administration of interventions such as high-dose chemotherapy or bone marrow transplantation should be guided by the IPSS scoring system. In younger patients, the timing of the administration of such interventions should involve a delicate balance between the risk of progression and their current life situation. In adults, meanwhile, palliation of symptoms and appropriate supportive care should be given more attention, as intensive interventions are not appropriate due to their medical conditions and performance status. In addition to discussing the pathology and aetiology of MDS, the chapter also discusses the classification of MDS, such as the FAB and WHO classifications; the overlapping features of MDS syndromes with other stem cell disorders; and the prognostic factors of MDS.

Keywords:   myelodysplastic syndromes, pre-leukaemic disorders, cytopenias, chemotherapy, bone marrow transplantation, pathology of MDS, aetiology of MDS, classification of MDS, FAB classification

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