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Palliative Care Consultations in Gynaeoncology$
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Sara Booth, Eduardo Bruera, and Teresa Tate

Print publication date: 2004

Print ISBN-13: 9780198528067

Published to Oxford Scholarship Online: November 2011

DOI: 10.1093/acprof:oso/9780198528067.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2019. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 11 December 2019

Thrombosis and bleeding problems in gynaecological malignancy

Thrombosis and bleeding problems in gynaecological malignancy

Chapter:
(p.117) Chapter 9 Thrombosis and bleeding problems in gynaecological malignancy
Source:
Palliative Care Consultations in Gynaeoncology
Author(s):

Dawn L. Alison

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198528067.003.0009

This chapter discusses thrombosis and bleeding problems in gynaecological malignancies. Venous thrombo-embolism (VTE) and bleeding problems are significant causes of morbidity and mortality in patients with cancer. Both cause distressing symptoms and pose management challenges, particularly in patients with advanced cancer. Patients experiencing such symptoms are often subjected to clotting and bleeding problems simultaneously. These symptoms are more prevalent in patients with gynaecological cancer because of the site of their cancer and the metastatic spread of their disease. Thrombosis is caused by the platelet activation by tumour cells, proagulant generation by tumour cells, increased level of clotting factors, and reduction of inhibitors. Bleeding problems on the other hand are caused by aggressive treatment, advancement of the disease, metastatic spread, Vitamin K deficiency, disseminated intravascular coagulation (DIC), and adverse drug effects. Also discussed in the chapter are the assessment of these symptoms and their management.

Keywords:   thrombosis, bleeding problems, venous thrombo-embolism, bleeding, clotting problems, platelet activation, proagulant generation, clotting factors, aggressive treatment, metastatic spread

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