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The Prefrontal CortexExecutive and Cognitive Functions$
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A. C. Roberts, T. W. Robbins, and L. Weiskrantz

Print publication date: 1998

Print ISBN-13: 9780198524410

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780198524410.001.0001

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A computational approach to prefrontal cortex, cognitive control, and schizophrenia: recent developments and current challenges

A computational approach to prefrontal cortex, cognitive control, and schizophrenia: recent developments and current challenges

Chapter:
(p.195) 14 A computational approach to prefrontal cortex, cognitive control, and schizophrenia: recent developments and current challenges
Source:
The Prefrontal Cortex
Author(s):

Jonathan D. Cohen

Todd S. Braver

Randall C. OʼReilly

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198524410.003.0014

This chapter explains computational modelling and reviews its initial progress to understand the role of prefrontal cortex in cognitive control, along with its impairment in schizophrenia. The chapter illustrates how such models can provide new insights into the mechanisms underlying cognitive control, can make new predictions about the behavioural performance of both normal and schizophrenic subjects, and provide examples of empirical support for such predictions. This not only provides a check on their conceptual validity, but also allows us to explore, in detail, their implications for behaviour. Success in this effort would not only provide insights into the mechanisms underlying some of our highest and uniquely human faculties, but might also allow to us to contend better with their failings, which appear to lie at the heart of our deepest vulnerabilities.

Keywords:   prefrontal cortex, schizophrenia, computational modelling, cognitive control, behaviour

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