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The Prefrontal CortexExecutive and Cognitive Functions$
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A. C. Roberts, T. W. Robbins, and L. Weiskrantz

Print publication date: 1998

Print ISBN-13: 9780198524410

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780198524410.001.0001

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Prefrontal function in schizophrenia: confounds and controversies

Prefrontal function in schizophrenia: confounds and controversies

(p.165) 12 Prefrontal function in schizophrenia: confounds and controversies
The Prefrontal Cortex

Daniel R. Weinberger

Karen Faith Berman

Oxford University Press

This chapter discusses the clinical and basic research that implicates prefrontal hypofunction in schizophrenia. Here, the chapter reviews functional neuroimaging studies of rCBF and of glucose utilization, wherein only around 60% of thirty-nine published reports could be interpreted as showing hypofrontality in patients with schizophrenia. The chapter explores prefrontal function during cognitive tasks in seven separate studies of independent samples of patients with schizophrenia. The data from these studies show that prefrontal function was reduced during cognitive states that enlisted prefrontal activation in normal subjects. Each of these studies involved paradigms that emphasized working memory. It conclusively suggests that the data from studies of other neurological disorders and of normal subjects who have difficulty with such tasks suggest that the finding in patients with schizophrenia is not the result of their poor performance, but rather is the likely explanation for it.

Keywords:   prefrontal function, schizophrenia, hypofunction, neuroimaging, cognitive states, neurological

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