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Current Methods in Muscle PhysiologyAdvantages, Problems and Limitations$
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Haruo Sugi

Print publication date: 1998

Print ISBN-13: 9780198523970

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780198523970.001.0001

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The use of peptide mimetics

The use of peptide mimetics

(p.133) 5 The use of peptide mimetics
Current Methods in Muscle Physiology

Harald Kögler

J. Caspar Rüegg

Oxford University Press

Muscle contraction totally depends on the two proteins actin and myosin. However, if they were the only proteins to exist in muscle, the ability to contract would be completely useless. It is the additional presence of the various regulatory proteins that enables the nervous system to determine when and where muscle contraction or relaxation is required for the benefit of the whole organism. Hence, in muscle cells a variety of protein–protein interactions occur in an orchestrated way, resulting in a mechanical response that is precisely controlled by the neural and/or humoral output of the central nervous system. To better understand not only the physiology but also the pathology of muscle contraction, it is vital to gain detailed insight into the nature of these protein–protein interactions. It is crucial, therefore, to identify the specific protein–recognition sites—if possible to the level of single amino acid residues—in order to be able to deduce the mechanisms of interaction.

Keywords:   muscle contraction, actin, myosin, regulatory proteins, protein–protein interactions, central nervous system

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