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Conditioned Taste AversionMemory of a Special Kind$
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Jan Bures, F. Bermudez-Rattoni, and T. Yamamoto

Print publication date: 1998

Print ISBN-13: 9780198523475

Published to Oxford Scholarship Online: January 2008

DOI: 10.1093/acprof:oso/9780198523475.001.0001

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Transplantation studies

Transplantation studies

Chapter:
(p.108) 8 Transplantation studies
Source:
Conditioned Taste Aversion
Author(s):

F. Bermúdez-Rattoni

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198523475.003.0008

Removed insular cortex (IC – about 3 mm3) can be substituted 60 days later by homotopic fetal IC transplant allowing CTA relearning. Similar attempts to compensate the lesioned amygdala by transplantation were less successful, probably because less HRP labelled cells regenerated in the Am than in the IC transplants. Recovery of CTA was absent after 15 days, poor after 30–45 days, and normal after 60 days following transplantation. Positive results were due to improved connectivity and to a higher content of trophic factors (NGF) and of acetyltransferase. In contrast, cholinergic blockade by scopolamine delayed the transplantation induced CTA recovery. Grafting fetal homotopic IC tissue allowed for a full recovery of the already learned CTA and learning CTA to novel taste. Grafting fetal occipital cortex into the lesioned IC allowed for recovery of the already established CTA but not any learning of new CTAs. This evidence indicates that the ‘reversibility’ of the ablation procedure is valid only when access to critical input and output centers remains preserved.

Keywords:   insular cortex, amygdala, transplantation, trophic factor, acetyltransferase, cholinergic blockade, scopolamine, occipital cortex, reversibility of ablation

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