Removed insular cortex (IC – about 3 mm3) can be substituted 60 days later by homotopic fetal IC transplant allowing CTA relearning. Similar attempts to compensate the lesioned amygdala by transplantation were less successful, probably because less HRP labelled cells regenerated in the Am than in the IC transplants. Recovery of CTA was absent after 15 days, poor after 30–45 days, and normal after 60 days following transplantation. Positive results were due to improved connectivity and to a higher content of trophic factors (NGF) and of acetyltransferase. In contrast, cholinergic blockade by scopolamine delayed the transplantation induced CTA recovery. Grafting fetal homotopic IC tissue allowed for a full recovery of the already learned CTA and learning CTA to novel taste. Grafting fetal occipital cortex into the lesioned IC allowed for recovery of the already established CTA but not any learning of new CTAs. This evidence indicates that the ‘reversibility’ of the ablation procedure is valid only when access to critical input and output centers remains preserved.
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