Jump to ContentJump to Main Navigation
Conditioned Taste AversionMemory of a Special Kind$
Users without a subscription are not able to see the full content.

Jan Bures, F. Bermudez-Rattoni, and T. Yamamoto

Print publication date: 1998

Print ISBN-13: 9780198523475

Published to Oxford Scholarship Online: January 2008

DOI: 10.1093/acprof:oso/9780198523475.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2019. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 18 November 2019

Pharmacology of CTA

Pharmacology of CTA

(p.60) 5 Pharmacology of CTA
Conditioned Taste Aversion

F. Bermúdez-Rattoni

Oxford University Press

While the CTA eliciting stimuli are restricted to the gustatory modality, the same substance can also be used as the US when it is ingested, and it influences the gastrointestinal system. Many drugs or treatments (chemotherapy or radiotherapy) triggering emesis may serve as the CTA eliciting US. The above development depends on species specific digestive processes, which explains why the same drug is well tolerated by some animals but entirely rejected by other animals. Similar mechanisms may explain CTA elicited by self-administered drugs (morphine, phencyclidine, cocaine, amphetamine), which may serve as aversive stimuli for CTA production. Another substance influencing food intake is cholecystokinine (CCK), a neuropeptide synthesized in the gut as a response to a meal, which may serve as a satiety factor. Injection of higher dosages of CCK (2μg/kg) may elicit CTA. CTA acquisition may be connected with poisoning induced stress or elicited by injection of cyclophosphamide.

Keywords:   chemotherapy, radiotherapy, emesis, self-administered drugs, morphine, phencyclidine, cocaine, amphetamine, cholecystokinine, satiety factor

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .