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Conditioned Taste AversionMemory of a Special Kind$
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Jan Bures, F. Bermudez-Rattoni, and T. Yamamoto

Print publication date: 1998

Print ISBN-13: 9780198523475

Published to Oxford Scholarship Online: January 2008

DOI: 10.1093/acprof:oso/9780198523475.001.0001

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Pharmacology of CTA

Pharmacology of CTA

Chapter:
(p.60) 5 Pharmacology of CTA
Source:
Conditioned Taste Aversion
Author(s):

F. Bermúdez-Rattoni

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198523475.003.0005

While the CTA eliciting stimuli are restricted to the gustatory modality, the same substance can also be used as the US when it is ingested, and it influences the gastrointestinal system. Many drugs or treatments (chemotherapy or radiotherapy) triggering emesis may serve as the CTA eliciting US. The above development depends on species specific digestive processes, which explains why the same drug is well tolerated by some animals but entirely rejected by other animals. Similar mechanisms may explain CTA elicited by self-administered drugs (morphine, phencyclidine, cocaine, amphetamine), which may serve as aversive stimuli for CTA production. Another substance influencing food intake is cholecystokinine (CCK), a neuropeptide synthesized in the gut as a response to a meal, which may serve as a satiety factor. Injection of higher dosages of CCK (2μg/kg) may elicit CTA. CTA acquisition may be connected with poisoning induced stress or elicited by injection of cyclophosphamide.

Keywords:   chemotherapy, radiotherapy, emesis, self-administered drugs, morphine, phencyclidine, cocaine, amphetamine, cholecystokinine, satiety factor

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