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The Neurobiology of Pain(Molecular and Cellular Neurobiology)$
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Stephen Hunt and Martin Koltzenburg

Print publication date: 2005

Print ISBN-13: 9780198515616

Published to Oxford Scholarship Online: January 2010

DOI: 10.1093/acprof:oso/9780198515616.001.0001

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Molecular biology of nociceptors

Molecular biology of nociceptors

Chapter:
(p.1) Chapter 1 Molecular biology of nociceptors
Source:
The Neurobiology of Pain
Author(s):

Michael J. Caterina

Michael S. Gold

Richard A. Meyer

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198515616.003.0001

This chapter begins with a functional classification of primary nociceptive neurons. It then presents current understanding of the molecules that allow nociceptors to detect noxious chemical, thermal, and mechanical stimuli. It describes the molecular processes by which this information is converted into action potentials and transmitted to the spinal cord. Finally, the chapter briefly describes the effects of an inflammatory insult on nociceptor function. For the sake of simplicity, it focuses primarily upon events related to cutaneous nociception.

Keywords:   nociceptive neurons, nociceptors, inflammation, cutaneous nociception, molecular mechanisms

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