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The Neurobiology of Pain(Molecular and Cellular Neurobiology)$
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Stephen Hunt and Martin Koltzenburg

Print publication date: 2005

Print ISBN-13: 9780198515616

Published to Oxford Scholarship Online: January 2010

DOI: 10.1093/acprof:oso/9780198515616.001.0001

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An integrative approach to the control of cancer pain

An integrative approach to the control of cancer pain

Chapter:
(p.375) Chapter 15 An integrative approach to the control of cancer pain
Source:
The Neurobiology of Pain
Author(s):

Patrick W. Mantyh

Tony L. Yaksh

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198515616.003.0015

This chapter discusses how cancer pain is generated and how the sensory information it initiates is processed as it moves from sense organ to the cerebral cortex under a constantly changing molecular architecture. Topics covered include primary afferent sensory neurons, tumour properties that excite nociceptors, tumour-induced release of protons and acidosis, tumor-induced distension and destruction of sensory fibers, and central sensitization in cancer pain.

Keywords:   cancer pain, tumor cells, nociceptors

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