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The Neurobiology of Pain(Molecular and Cellular Neurobiology)$
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Stephen Hunt and Martin Koltzenburg

Print publication date: 2005

Print ISBN-13: 9780198515616

Published to Oxford Scholarship Online: January 2010

DOI: 10.1093/acprof:oso/9780198515616.001.0001

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An integrative approach to the control of cancer pain

An integrative approach to the control of cancer pain

(p.375) Chapter 15 An integrative approach to the control of cancer pain
The Neurobiology of Pain

Patrick W. Mantyh

Tony L. Yaksh

Oxford University Press

This chapter discusses how cancer pain is generated and how the sensory information it initiates is processed as it moves from sense organ to the cerebral cortex under a constantly changing molecular architecture. Topics covered include primary afferent sensory neurons, tumour properties that excite nociceptors, tumour-induced release of protons and acidosis, tumor-induced distension and destruction of sensory fibers, and central sensitization in cancer pain.

Keywords:   cancer pain, tumor cells, nociceptors

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