Headache is among the most fascinating and most common of medical problems. It can be a manifestation of a disease process in its own right, without a clearly defined other cause (primary headaches such as migraine, tension-type headache, or cluster headache), or headache can be due to a defined other disease process, such as that associated with infection, brain tumour, or head trauma. This chapter discusses the common biology of pain processing for headache, since it is likely to be shared to some extent by most forms of headache. It then presents the unique biology that underlies migraine as a form of primary headache that exemplifies some of the basic principles of headache biology.
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