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Molecular Biology of the Neuron$
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R. Wayne Davies and Brian Morris

Print publication date: 2004

Print ISBN-13: 9780198509981

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780198509981.001.0001

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Protein trafficking in neurons

Protein trafficking in neurons

Chapter:
(p.75) Chapter 4 Protein trafficking in neurons
Source:
Molecular Biology of the Neuron
Author(s):

Christopher N. Connolly

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198509981.003.0004

Recent advances in molecular and cell biological technologies have enhanced our knowledge of protein trafficking in neurons. Although neurons were initially thought to be intractable to transfection, improvements in culture conditions and perseverance in the development of transfection protocols have paid off. It is now possible to culture polarized neurons and express recombinant proteins by a variety of methods including: intranuclear microinjection, DNA biolistics (DNA-gun), viral vectors, and more classical approaches such as calcium phosphate precipitation, electroporation, and liposome-based protocols. This chapter discusses regulated transport to the trans-Golgi network, morphology, polarity development, polarity in mature neurons, polarity signals, postsynaptic targeting, and postsynaptic removal of receptors.

Keywords:   neurons, protein trafficking, polarity, DNA-gun, regulated transport

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