Jump to ContentJump to Main Navigation
Molecular Biology of the Neuron$
Users without a subscription are not able to see the full content.

R. Wayne Davies and Brian Morris

Print publication date: 2004

Print ISBN-13: 9780198509981

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780198509981.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2020. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 03 June 2020

Protein trafficking in neurons

Protein trafficking in neurons

(p.75) Chapter 4 Protein trafficking in neurons
Molecular Biology of the Neuron

Christopher N. Connolly

Oxford University Press

Recent advances in molecular and cell biological technologies have enhanced our knowledge of protein trafficking in neurons. Although neurons were initially thought to be intractable to transfection, improvements in culture conditions and perseverance in the development of transfection protocols have paid off. It is now possible to culture polarized neurons and express recombinant proteins by a variety of methods including: intranuclear microinjection, DNA biolistics (DNA-gun), viral vectors, and more classical approaches such as calcium phosphate precipitation, electroporation, and liposome-based protocols. This chapter discusses regulated transport to the trans-Golgi network, morphology, polarity development, polarity in mature neurons, polarity signals, postsynaptic targeting, and postsynaptic removal of receptors.

Keywords:   neurons, protein trafficking, polarity, DNA-gun, regulated transport

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .