Jump to ContentJump to Main Navigation
The Weak Hydrogen BondIn Structural Chemistry and Biology$
Users without a subscription are not able to see the full content.

Gautam Desiraju and Thomas Steiner

Print publication date: 2001

Print ISBN-13: 9780198509707

Published to Oxford Scholarship Online: January 2010

DOI: 10.1093/acprof:oso/9780198509707.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2019. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 16 October 2019

The weak hydrogen bond in supramolecular chemistry

The weak hydrogen bond in supramolecular chemistry

(p.293) 4 The weak hydrogen bond in supramolecular chemistry
The Weak Hydrogen Bond



Oxford University Press

This chapter reviews the weak hydrogen bond in supramolecular chemistry by focusing on the relevance of these interactions in the analysis, design, and synthesis of the structures of molecular assemblies, most notably crystals. Supramolecular chemistry signifies chemistry beyond the molecule and deals with implications of the fact that molecules can recognise one another via intermolecular interactions, typically in condensed media. This field has grown into two distinct branches: the study of supermolecules in solution and in the solid state, mainly in crystal structures. The most important distinction between these two situations is not structural but lies in the lifetime of the interactions − supramolecular association in the crystal is time-stable whereas in solution it is not. The present chapter mainly concentrates on solid-state supramolecular systems, and discusses the role of weak hydrogen bonds in inclusion complexes such as crown ethers, oligoaryl hosts, and cyclodextrins (cycloamyloses). The promises and problems of crystal engineering are also considered, together with drug design and biological recognition.

Keywords:   supramolecular chemistry, supermolecules, solid state, crystal structures, crystal engineering, supramolecular association, inclusion complexes, drug design, biological recognition

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .