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Human Genome Epidemiology, 2nd EditionBuilding the evidence for using genetic information to improve health and prevent disease$
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Muin Khoury, Sara Bedrosian, Marta Gwinn, Julian Higgins, John Ioannidis, and Julian Little

Print publication date: 2009

Print ISBN-13: 9780195398441

Published to Oxford Scholarship Online: May 2010

DOI: 10.1093/acprof:oso/9780195398441.001.0001

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The challenge of assessing complex gene– environment and gene–gene interactions

The challenge of assessing complex gene– environment and gene–gene interactions

Chapter:
(p.165) 9 The challenge of assessing complex gene– environment and gene–gene interactions
Source:
Human Genome Epidemiology, 2nd Edition
Author(s):

Peter Kraft

David J. Hunter

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195398441.003.0009

This chapter discusses the study of gene-environment and gene-gene interactions in genetic epidemiology. It starts with a review of the definition of statistical gene-environment interaction, which is what is typically measured and reported in genetic association studies, and contrasts this with specific theoretical and general intuitive models for biologic interaction. It then describes how these concepts can be extended to the study of gene-gene interactions, and reviews available study designs, with particular emphasis on estimating joint gene-environment and gene-gene effects.

Keywords:   gene-environment interactions, gene-gene interactions, genetic epidemiology

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