Jump to ContentJump to Main Navigation
Human Genome Epidemiology, 2nd EditionBuilding the evidence for using genetic information to improve health and prevent disease$
Users without a subscription are not able to see the full content.

Muin Khoury, Sara Bedrosian, Marta Gwinn, Julian Higgins, John Ioannidis, and Julian Little

Print publication date: 2009

Print ISBN-13: 9780195398441

Published to Oxford Scholarship Online: May 2010

DOI: 10.1093/acprof:oso/9780195398441.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2020. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 26 May 2020

The human epigenome and cancer

The human epigenome and cancer

(p.551) 28 The human epigenome and cancer
Human Genome Epidemiology, 2nd Edition

Mukesh Verma

Oxford University Press

Epigenetics, the study of mechanisms that involve mitotically heritable changes in DNA other than changes in nucleotide sequence, represents a new frontier in research, especially in cancer. Most of our cells contain the same DNA, yet gene expression varies dramatically among different tissues. Epigenetic mechanisms establish and maintain this tissue-specific gene expression. Various chemicals (such as nickel, arsenic, cadmium), certain base analogs, radiation, smoke, stress, hormones (such as estradiol), and reactive oxygen species can alter the phenotypes of mammalian cells, via epigenetic mechanisms, without changing the underlying DNA sequence. These agents can alter the methylation and/or acetylation state of the DNA. Contrary to mutations, epigenetic changes can be reversed by chemicals and thus provide opportunities for development of intervention and treatment strategies. Epigenetic markers could be used in cancer detection, diagnosis, prognosis, and epidemiology. This chapter discusses research opportunities at the National Cancer Institute (NCI), one of the 27 Institutes and Centers at the National Institutes of Health (NIH), and efforts to complete human epigenome.

Keywords:   epigenomics, clinical practice, disease prevention, cancer epigenetics, National Cancer Institute

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .