Jump to ContentJump to Main Navigation
Human Genome Epidemiology, 2nd EditionBuilding the evidence for using genetic information to improve health and prevent disease$
Users without a subscription are not able to see the full content.

Muin Khoury, Sara Bedrosian, Marta Gwinn, Julian Higgins, John Ioannidis, and Julian Little

Print publication date: 2009

Print ISBN-13: 9780195398441

Published to Oxford Scholarship Online: May 2010

DOI: 10.1093/acprof:oso/9780195398441.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2020. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 26 May 2020

Coronary heart disease

Coronary heart disease

(p.369) 19 Coronary heart disease
Human Genome Epidemiology, 2nd Edition

Adam S. Butterworth

Julian P. T. Higgins

Nadeem Sarwar

John Danesh

Oxford University Press

Coronary heart disease (CHD) — which includes myocardial infarction, angina pectoris, and stenosis of the coronary arteries — is the leading cause of death worldwide, with over 7 million deaths per year. The tendency for CHD to cluster in families suggests that genetic variation, either directly or through modulation of known or as yet unidentified risk factors, importantly influences CHD risk. This chapter provides a critical and quantitative review of the current state of evidence regarding potential genetic susceptibility loci and CHD. It reviews published quantitative reviews of candidate gene polymorphisms and published GWAS addressing CHD.

Keywords:   genetic variants, genetic variations, human disease, genome-wide studies, coronary heart disease, risk factors

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .