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Human Genome Epidemiology, 2nd EditionBuilding the evidence for using genetic information to improve health and prevent disease$
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Muin Khoury, Sara Bedrosian, Marta Gwinn, Julian Higgins, John Ioannidis, and Julian Little

Print publication date: 2009

Print ISBN-13: 9780195398441

Published to Oxford Scholarship Online: May 2010

DOI: 10.1093/acprof:oso/9780195398441.001.0001

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Childhood leukemias

Childhood leukemias

(p.278) 14 Childhood leukemias
Human Genome Epidemiology, 2nd Edition

Anand P. Chokkalingam

Patricia A. Buffler

Oxford University Press

The term “leukemia” refers broadly to cancer of the white blood cells, or leukocytes. As a group, leukemias are the most common cancer among people under 15 years of age, accounting for 32% of all childhood malignancies. This chapter summarizes the total body of literature on the genetic epidemiology of childhood leukemias, focusing specifically on main effects of gene variants, highlighting conclusions that can be drawn based on the work to date, and emphasizing challenges and future directions.

Keywords:   genetic variants, genetic variations, human disease, genome-wide studies, leukemia

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