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The History of Neuroscience in AutobiographyVolume 7$
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Larry R. Squire

Print publication date: 2011

Print ISBN-13: 9780195396133

Published to Oxford Scholarship Online: January 2012

DOI: 10.1093/acprof:oso/9780195396133.001.0001

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Nicole M. Le Douarin

Nicole M. Le Douarin

Nicole M. Le Douarin
The History of Neuroscience in Autobiography

Larry R. Squire

Oxford University Press

Nicole Le Douarin began her research career while a high school teacher. Her PhD work under the supervision of Etienne Wolff was on the development of the digestive tract and liver in the chick embryo. She later devised a cell marking technique based on the construction of chimeras by combining cells of quail and chick embryos in ovo. Using this technique she demonstrated that the neural crest is a major player in vertebrate embryogenesis, namely by its role in the development of the head and brain. She demonstrated with her colleagues the existence of a stem cell in the Neural Crest, the first example of a neural stem cell. She and her group applied the quail-chick chimera system to other problems such as hematopoiesis and demonstrated a novel mechanism of tolerance to self.

Keywords:   chick embryo, neural crest, embryogenesis, development, neural stem cell

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