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Integrative Neuroscience and Personalized Medicine$
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Evian Gordon, MD, PhD and Stephen Koslow, PhD

Print publication date: 2010

Print ISBN-13: 9780195393804

Published to Oxford Scholarship Online: January 2011

DOI: 10.1093/acprof:oso/9780195393804.001.0001

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The Role of Neuroimaging Biomarkers in Personalized Medicine for Neurodegenerative and Psychiatric Disorders

The Role of Neuroimaging Biomarkers in Personalized Medicine for Neurodegenerative and Psychiatric Disorders

Chapter:
(p.141) 8 The Role of Neuroimaging Biomarkers in Personalized Medicine for Neurodegenerative and Psychiatric Disorders
Source:
Integrative Neuroscience and Personalized Medicine
Author(s):

Ellen M. Migo

Steve C.R. Williams

William R. Crum

Matthew J. Kempton

Ulrich Ettinger

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195393804.003.0008

There is a clear need for biomarkers in neuro-degenerative and psychiatric disorders for both early and differential diagnosis, personalized prediction of treatment response, and in drug discovery. Non-invasive neuroimaging is a key area for biomarker development because it connects behavioural outcomes with structural, functional, and molecular mechanisms. This chapter discusses neuroimaging biomarkers in relation to dementia, schizophrenia, and mood disorders (bipolar and major depressive disorders). The current candidate biomarkers for each disorder are reviewed, across the full range of imaging modalities, followed by an evaluation of their future prospects. The chapter concludes that there has been substantial progress towards personalized neuroimaging-based biomarkers but much remains to be done. Such biomarkers must be validated for specific disorders and may include neuroimaging and non-neuroimaging components.

Keywords:   neuroimaging, biomarkers, dementia, schizophrenia, mood disorders, bipolar disorder, major depressive disorder

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