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Integrative Neuroscience and Personalized Medicine$
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Evian Gordon, MD, PhD and Stephen Koslow, PhD

Print publication date: 2010

Print ISBN-13: 9780195393804

Published to Oxford Scholarship Online: January 2011

DOI: 10.1093/acprof:oso/9780195393804.001.0001

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Personalized Integrative Markers for Attention Deficit/Hyperactivity Disorder in Children and Adolescents

Personalized Integrative Markers for Attention Deficit/Hyperactivity Disorder in Children and Adolescents

Chapter:
(p.117) 7 Personalized Integrative Markers for Attention Deficit/Hyperactivity Disorder in Children and Adolescents
Source:
Integrative Neuroscience and Personalized Medicine
Author(s):

Michael R. Kohn

Simon D. Clarke

Leanne M. Williams

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195393804.003.0007

Attention Deficit Hyperactivity Disorder (ADHD) is the most common disorder of childhood-adolescent brain health. Here, we take an integrative neuroscience approach to personalized medicine. The goal of this approach is: 1) to identify promising markers that bridge cognitive and brain measures, as well as genomics; these currently have value for supporting diagnostic and personalized treatment decisions in clinical practice. These markers are sensitive and specific for distinguishing ADHD, focusing on the triad of inattention, hyperactivity and impulsivity. These markers are assessed with straightforward cognitive tests that relate to brain function and genes affecting dopamine. The same markers are also implicated in predicting response to stimulants. A different set of markers capturing alterations in emotion, feeling and their regulation shows promise in identifying comorbid internalizing conditions, such as anxiety, and externalizing conditions, such as conduct disorder.

Keywords:   Attention deficit hyperactivity disorder, Personalized medicine, Integrative neuroscience, cognition, brain, gene, marker, clinical decision support, anxiety, conduct disorder

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