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Integrative Neuroscience and Personalized Medicine$
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Evian Gordon, MD, PhD and Stephen Koslow, PhD

Print publication date: 2010

Print ISBN-13: 9780195393804

Published to Oxford Scholarship Online: January 2011

DOI: 10.1093/acprof:oso/9780195393804.001.0001

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Personalized Medicine for Schizophrenia

Personalized Medicine for Schizophrenia

(p.93) 6 Personalized Medicine for Schizophrenia
Integrative Neuroscience and Personalized Medicine

Jacob S. Ballon

Ragy R. Girgis

Jeffrey A. Lieberman

Oxford University Press

This chapter discusses the potential for personalized medicine as it applies to schizophrenia, one of the most severe mental disorders. The first half of this chapter will address the genetics of schizophrenia, and in particular what is known about the pharmacogenomics of treatment response and side effects. The second half will focus on the neurobiology and physical abnormalities of schizophrenia, and discuss these in the context of endophenotypes and biomarkers of the illness. Finally, this chapter will conclude with a synthesis of the previously discussed genetic and neurobiological findings in schizophrenia and ideas on how this knowledge can be translated into the framework of personalized medicine.

Keywords:   personalized medicine, schizophrenia, pharmacogenomics, neurobiology, endophenotypes, biomarkers

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