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Imaging in Parkinson’s Disease$
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David Eidelberg

Print publication date: 2011

Print ISBN-13: 9780195393484

Published to Oxford Scholarship Online: September 2011

DOI: 10.1093/acprof:oso/9780195393484.001.0001

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Dopaminergic Imaging in Parkinson’s Disease: SPECT

Dopaminergic Imaging in Parkinson’s Disease: SPECT

(p.11) 2 Dopaminergic Imaging in Parkinson’s Disease: SPECT
Imaging in Parkinson’s Disease

Christoph Scherfler

Werner Poewe

Oxford University Press

The diagnosis of idiopathic Parkinson’s disease (PD) can often be made on clinical grounds with a high degree of accuracy particularly in cases with full expression of the classical motor features of the illness. Nonetheless, considerable diagnostic uncertainty can exist at early disease stages, particularly when clinical signs are subtle or equivocal. This chapter focuses on methodological aspects of dopamine transporter (DAT) SPECT, its role in assessing PD progression, and its potential use in the diagnosis of atypical parkinsonism. The chapter also examines the application of this tool to the study of clinically relevant pathologies such as psychogenic, vascular and drug-induced parkinsonism, dementia with Lewy bodies, and essential tremor. The chapter also addresses the potential of DAT-SPECT to identify subjects at risk for PD will be discussed.

Keywords:   dopamine transporter, single photon emission computed tomography, atypical parkinsonism, drug-induced parkinsonism, Parkinson’s disease progression, at-risk subjects

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