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Reproductive and Perinatal Epidemiology$
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Germaine M. Buck Louis and Robert W. Platt

Print publication date: 2011

Print ISBN-13: 9780195387902

Published to Oxford Scholarship Online: May 2011

DOI: 10.1093/acprof:oso/9780195387902.001.0001

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Unique Methodologic Challenges in Reproductive and Perinatal Epidemiology

Unique Methodologic Challenges in Reproductive and Perinatal Epidemiology

Chapter:
(p.298) 16 Unique Methodologic Challenges in Reproductive and Perinatal Epidemiology
Source:
Reproductive and Perinatal Epidemiology
Author(s):

Robert W. Platt (Contributor Webpage)

Germaine M. Buck Louis (Contributor Webpage)

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195387902.003.0098

Reproductive and perinatal epidemiology has a number of unique challenges that require careful attention when designing research and analyzing data. These include conceptual considerations such as defining critical and sensitive windows consistent with the highly interrelated and timed nature of human reproduction and development, and measuring maternal, paternal or parental exposures for couple dependent outcomes such as pregnancy. Methodologic considerations discussed in the chapter include the known clustering of study outcomes such as successive pregnancies, multiple births or consecutive infertility treatment cycles, along with interval censoring and truncation issues. In addition, the chapter reviews modeling strategies suitable for addressing clustered outcomes such as hierarchical and semi-parametric models, and methods for addressing censoring and truncation.

Keywords:   censoring, truncation, clustering, epidemiology, hierarchical models, methods, semi-parametric models

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