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Reproductive and Perinatal Epidemiology$
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Germaine M. Buck Louis and Robert W. Platt

Print publication date: 2011

Print ISBN-13: 9780195387902

Published to Oxford Scholarship Online: May 2011

DOI: 10.1093/acprof:oso/9780195387902.001.0001

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Sensitive Windows of Human Reproduction and Development

Sensitive Windows of Human Reproduction and Development

(p.16) 2 Sensitive Windows of Human Reproduction and Development
Reproductive and Perinatal Epidemiology

Germaine M. Buck Louis (Contributor Webpage)

Oxford University Press

Successful human reproduction and development is dependent upon men and women undergoing a series of highly interrelated and conditional biologic processes, many of which delineate critical or sensitive windows of human development. This chapter provides an overview of six sensitive windows including folliculogenesis, spermatogenesis and steriodogenesis, menstruation, ovulation and the fertile window, implantation window, and the intrauterine environment. Understanding the biology of these sensitive windows has methodologic implications for study design and the timing of data and biospecimens collection, particularly when attempting to identify fecundity determinants or reproductive and/or developmental toxicants. Sensitive windows are highly relevant for assessing the early origins of health and disease including the elucidation of epigenetic mechanisms that impact human reproduction and development across the lifespan and, possibly, across generations.

Keywords:   development, folliculogenesis, implantation, in utero, menstruation, ovulation, human reproduction, sensitive window, spermatogenesis

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