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The History of Neuroscience in Autobiography Volume 6$
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Larry R Squire

Print publication date: 2009

Print ISBN-13: 9780195380101

Published to Oxford Scholarship Online: May 2009

DOI: 10.1093/acprof:oso/9780195380101.001.0001

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Leslie L. Iversen

Leslie L. Iversen

(p.189) Leslie L. Iversen
The History of Neuroscience in Autobiography Volume 6

Larry R. Squire

Oxford University Press

This chapter presents an autobiography of Leslie L. Iversen. Iversen has been at the forefront of research on neurotransmitters and neuropeptides and understanding the mode of action of CNS drugs. He was among the first to describe the detailed properties and pharmacological specificity of the noradrenaline transporter (NAT) in sympathetic nerves and brain, and he helped to strengthen the concept of antipsychotic drugs as dopamine receptor antagonists. He participated in the first demonstration of the release of GABA on activation of an inhibitory synapse, and was the first to describe GABA uptake into inhibitory nerve endings in mammalian brain. His early years, career and achievements are discussed.

Keywords:   CNS drugs, NAT, sympathetic nerves, neurotransmitters, neuropeptides, noradrenaline transporter, GABA

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