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Dopamine Handbook$
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Leslie Iversen, Susan Iversen, Stephen Dunnett, and Anders Bjorklund

Print publication date: 2009

Print ISBN-13: 9780195373035

Published to Oxford Scholarship Online: February 2010

DOI: 10.1093/acprof:oso/9780195373035.001.0001

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Dopamine and Synaptic Plasticity in Mesolimbic Circuits

Dopamine and Synaptic Plasticity in Mesolimbic Circuits

Chapter:
(p.339) 7.2 Dopamine and Synaptic Plasticity in Mesolimbic Circuits
Source:
Dopamine Handbook
Author(s):

F. Woodward Hopf

Antonello Bonci

Robert C. Malenka

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195373035.003.0024

This chapter reviews current understanding of how dopamine (DA) might modulate glutamatergic synaptic plasticity in mesolimbic brain regions. This topic is examined in the context of in vitro brain slice experiments and plasticity induction in the anesthetized animal. The possibility that DA modulation of glutamatergic signaling could occur in the awake animal and contribute to the expression of motivated behavior is discussed.

Keywords:   dopamine, glutamatergic synaptic plasticity, mesolimbic system, motivation behavior

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