Jump to ContentJump to Main Navigation
Dopamine Handbook$
Users without a subscription are not able to see the full content.

Leslie Iversen, Susan Iversen, Stephen Dunnett, and Anders Bjorklund

Print publication date: 2009

Print ISBN-13: 9780195373035

Published to Oxford Scholarship Online: February 2010

DOI: 10.1093/acprof:oso/9780195373035.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2019. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a monograph in OSO for personal use (for details see www.oxfordscholarship.com/page/privacy-policy).date: 19 June 2019

Contributions of Mesocorticolimbic Dopamine to Cognition and Executive Function

Contributions of Mesocorticolimbic Dopamine to Cognition and Executive Function

(p.215) 5.2 Contributions of Mesocorticolimbic Dopamine to Cognition and Executive Function
Dopamine Handbook

Stan B. Floresco

Oxford University Press

This chapter presents a summary of studies that have investigated the contribution of prefrontal cortex (PFC) dopamine (DA) transmission to higher-order cognition, and compares and contrasts the specific DA receptor mechanisms that regulate different types of executive function. Viewed collectively, the findings reviewed suggest that dopaminergic input to the forebrain, including the frontal lobes and the dorsal and ventral striatum, forms an essential component of the neural circuits that mediate a variety of cognitive and executive functions, including working memory and different forms of behavioral flexibility. Both of these executive functions engage distinct types of cognitive operations and functional neural circuits. Therefore, it is not surprising that the receptor mechanisms by which DA exerts its effects are not unitary across these functions; instead, each type of process relies on different patterns of activation of DA receptors in the PFC and the striatum.

Keywords:   dopamine receptors, prefrontal cortex, dopamine transmission, striatum, cognitive function, executive function, working memory

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .