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Dopamine Handbook$
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Leslie Iversen, Susan Iversen, Stephen Dunnett, and Anders Bjorklund

Print publication date: 2009

Print ISBN-13: 9780195373035

Published to Oxford Scholarship Online: February 2010

DOI: 10.1093/acprof:oso/9780195373035.001.0001

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Contributions of Mesocorticolimbic Dopamine to Cognition and Executive Function

Contributions of Mesocorticolimbic Dopamine to Cognition and Executive Function

Chapter:
(p.215) 5.2 Contributions of Mesocorticolimbic Dopamine to Cognition and Executive Function
Source:
Dopamine Handbook
Author(s):

Stan B. Floresco

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195373035.003.0015

This chapter presents a summary of studies that have investigated the contribution of prefrontal cortex (PFC) dopamine (DA) transmission to higher-order cognition, and compares and contrasts the specific DA receptor mechanisms that regulate different types of executive function. Viewed collectively, the findings reviewed suggest that dopaminergic input to the forebrain, including the frontal lobes and the dorsal and ventral striatum, forms an essential component of the neural circuits that mediate a variety of cognitive and executive functions, including working memory and different forms of behavioral flexibility. Both of these executive functions engage distinct types of cognitive operations and functional neural circuits. Therefore, it is not surprising that the receptor mechanisms by which DA exerts its effects are not unitary across these functions; instead, each type of process relies on different patterns of activation of DA receptors in the PFC and the striatum.

Keywords:   dopamine receptors, prefrontal cortex, dopamine transmission, striatum, cognitive function, executive function, working memory

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