Jump to ContentJump to Main Navigation
Dopamine Handbook$
Users without a subscription are not able to see the full content.

Leslie Iversen, Susan Iversen, Stephen Dunnett, and Anders Bjorklund

Print publication date: 2009

Print ISBN-13: 9780195373035

Published to Oxford Scholarship Online: February 2010

DOI: 10.1093/acprof:oso/9780195373035.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2019. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 22 November 2019

From Behavior to Cognition: Functions of Mesostriatal, Mesolimbic, and Mesocortical Dopamine Systems

From Behavior to Cognition: Functions of Mesostriatal, Mesolimbic, and Mesocortical Dopamine Systems

Chapter:
(p.203) 5.1 From Behavior to Cognition: Functions of Mesostriatal, Mesolimbic, and Mesocortical Dopamine Systems
Source:
Dopamine Handbook
Author(s):

Trevor W. Robbins

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195373035.003.0014

This chapter reviews the role of dopamine (DA) in mesostriatal, mesolimbic, and mesocortical systems in experimental animals and humans. It appears that each of these systems is “tuned” according to an inverted U-shaped function, such that either too low or too high levels of DA activity will produce impaired performance, whether in the motor, behavioral, or cognitive domains. This tuning probably varies among the major terminal domains, each of which may function optimally at a different level of DA activity. Related to this observation is the evidence that different cognitive tasks also appear to be performed optimally at different levels of DA function. In addition to this complexity, it appears that individuals vary in their degree of dopaminergic tuning, at least partly because of factors such as genetic polymorphisms.

Keywords:   cognition, mesencephalic dopamine system, mesocortical dopamine system

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .