Jump to ContentJump to Main Navigation
Dopamine Handbook$
Users without a subscription are not able to see the full content.

Leslie Iversen, Susan Iversen, Stephen Dunnett, and Anders Bjorklund

Print publication date: 2009

Print ISBN-13: 9780195373035

Published to Oxford Scholarship Online: February 2010

DOI: 10.1093/acprof:oso/9780195373035.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2019. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 17 October 2019

Genetic Dissection of Dopamine-Mediated Prefrontal-Striatal Mechanisms and Its Relationship to Schizophrenia

Genetic Dissection of Dopamine-Mediated Prefrontal-Striatal Mechanisms and Its Relationship to Schizophrenia

Chapter:
(p.187) 4.4 Genetic Dissection of Dopamine-Mediated Prefrontal-Striatal Mechanisms and Its Relationship to Schizophrenia
Source:
Dopamine Handbook
Author(s):

Hao-Yang Tan

Daniel R. Weinberger

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195373035.003.0013

This chapter examines findings through which heritable human neuroimaging intermediate phenotypes could provide a window to examine genetic mechanisms of active prefrontal cognitive processing related to dopamine (DA). Genetic variation influencing task-related prefrontal cortical function was consistent with fundamental predictions based on the biology of DA tuning in cortical microcircuits. These findings also extended the basic biological data to implicate molecules impacting variation in active human brain function, potentially mirroring component disease-related brain processes in schizophrenia. The findings of interacting genetic elements consistent with the cross-talk within and across DA and glutamatergic systems, and their intracellular signaling pathways, arguably contribute further empirical validation to the strategy to identify molecules whose genetic variation could be of substantial combined influence on human brain function at the network or systems level.

Keywords:   dopamine processing, cognitive functions, schizophrenia, neuroimaging, cognition

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .