- Title Pages
- Dedication
- Preface
- Acknowledgments
- I.1 Fundamentals of Electricity
- I.2 Patch-Clamp Recording
- I.3 Physical Basis for the Resting Potential
- I.4 Basis of the Nerve Impulse
- I.5 Properties of Neurons
- I.6 Electrophysiology of Neuronal Interactions
- I.7 Neuronal Oscillators
- SECTION II DESCRIPTION OF THE MODELS
- II.1 Electricity Model
- II.2 Patch Model
- II.3 Soma Model
- II.4 Axon Models
- II.5 Neuron Model
- II.6 Synapse Model
- II.7 Circuit Model
- II.8 Stimulator Control
- SECTION III EQUATIONS UNDERLYING NEURODYNAMIX II SIMULATIONS
- III.1 Equations Underlying the Electricity Model
- III.2 Equations Underlying the Patch Model
- III.3 Equations Underlying the Soma Model
- III.4 Equations Underlying the Axon Models
- III.5 Equations Underlying the Neuron Model
- III.6 Equations Underlying the Synapse Model
- III.7 Equations Underlying the Circuit Model
- IV.1 Form of the Equations
- IV.2 Numerical Solution
- Guide to <i>NeuroDynamix II</i> Software
- Bibliography
- Index
Patch-Clamp Recording
Patch-Clamp Recording
- Chapter:
- (p.20) I.2 Patch-Clamp Recording
- Source:
- NeuroDynamix II
- Author(s):
W. Otto Friesen
Jonathon A. Friesen
- Publisher:
- Oxford University Press
Invented by Bert Sakmann and Erwin Neher during the 1970s, the patch-clamp recording technique aids scientists in examining the functions of individual protein molecules that form ion channels in cell membranes. The importance of this outstanding contribution, which has revolutionized neurophysiology and greatly augmented understanding of cell membranes, is underscored by the fact that Sakmann and Neher received the Nobel Prize in 1991. The fundamental finding arising from patch-clamp experiments is that currents through cell membranes pass through protein channels. This chapter provides a brief introduction to the patch-clamp technique and presents the fundamental equations that govern currents through individual ion channels. The electrophysiology of three types of ion channels is described: nongated chloride channels, voltage-gated sodium and potassium channels, and ligand-gated acetylcholine channels.
Keywords: patch clamp, ion channel, gating, conductance, channel protein, current
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- Title Pages
- Dedication
- Preface
- Acknowledgments
- I.1 Fundamentals of Electricity
- I.2 Patch-Clamp Recording
- I.3 Physical Basis for the Resting Potential
- I.4 Basis of the Nerve Impulse
- I.5 Properties of Neurons
- I.6 Electrophysiology of Neuronal Interactions
- I.7 Neuronal Oscillators
- SECTION II DESCRIPTION OF THE MODELS
- II.1 Electricity Model
- II.2 Patch Model
- II.3 Soma Model
- II.4 Axon Models
- II.5 Neuron Model
- II.6 Synapse Model
- II.7 Circuit Model
- II.8 Stimulator Control
- SECTION III EQUATIONS UNDERLYING NEURODYNAMIX II SIMULATIONS
- III.1 Equations Underlying the Electricity Model
- III.2 Equations Underlying the Patch Model
- III.3 Equations Underlying the Soma Model
- III.4 Equations Underlying the Axon Models
- III.5 Equations Underlying the Neuron Model
- III.6 Equations Underlying the Synapse Model
- III.7 Equations Underlying the Circuit Model
- IV.1 Form of the Equations
- IV.2 Numerical Solution
- Guide to <i>NeuroDynamix II</i> Software
- Bibliography
- Index
