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From Development to Degeneration and Regeneration of the Nervous System$
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Charles E. Ribak, Carlos Aramburo de la Hoz, Edward G. Jones, Jorge A. Larriva Sahd, and Larry W. Swanson

Print publication date: 2008

Print ISBN-13: 9780195369007

Published to Oxford Scholarship Online: May 2009

DOI: 10.1093/acprof:oso/9780195369007.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2019. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 20 October 2019

Human Neural Stem Cell–Mediated Repair of the Contused Spinal Cord: Timing the Microenvironment

Human Neural Stem Cell–Mediated Repair of the Contused Spinal Cord: Timing the Microenvironment

Chapter:
(p.297) Chapter Fifteen Human Neural Stem Cell–Mediated Repair of the Contused Spinal Cord: Timing the Microenvironment
Source:
From Development to Degeneration and Regeneration of the Nervous System
Author(s):

Brian J. Cummings

Mitra J. Hooshmand

Desirée L. Salazar

Aileen J. Anderson

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195369007.003.0015

Spinal cord injury (SCI) is a debilitating and devastating condition that affects approximately 11,000 new people in the United States each year. Understanding of the pathophysiology and potential points of therapeutic intervention for human SCI has been shaped strongly by the results of studies performed in laboratory animals. This chapter discusses multiple targets for therapeutic interventions focusing on cell transplantation approaches, discusses the application of multiple cells types in SCI models, and considers how cell-intrinsic properties as well as exogenous factors in the host microenvironment may influence the ability of various cell populations to survive, differentiate, and promote locomotor recovery following SCI. Studies conducted on transplanting human central nervous system-derived neural stem cells (HuCNS-SCs) at selected time points along the acute to chronic continuum are described, demonstrating that, depending on timing, HuCNS-SCs have the ability to promote locomotor recovery and that the microenvironment influences cell fate.

Keywords:   spinal cord injury, regeneration, stem cells, therapeutic intervention, transplantation, HuCNS-SCs

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