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Cortical Oscillations in Health and Disease$
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Roger Traub, MD and Miles Whittington, PhD

Print publication date: 2010

Print ISBN-13: 9780195342796

Published to Oxford Scholarship Online: May 2010

DOI: 10.1093/acprof:oso/9780195342796.001.0001

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Epileptiform Discharges In Vitro

Epileptiform Discharges In Vitro

Chapter:
(p.302) 13 Epileptiform Discharges In Vitro
Source:
Cortical Oscillations in Health and Disease
Author(s):

Roger D. Roger

Miles A. Whittington

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195342796.003.0013

VFO precedes electrographic seizures in vitro, as well as in vivo. The in vitro VFO is gap junction dependent, and is observed most readily in conditions when synaptic transmission is suppressed. One hypothesis as to seizure initiation is that synaptic excitation recovers prior to synaptic inhibition, so that classical synaptically mediated seizure discharges can arise. Epileptiform discharges in vivo can also be preceded by gamma oscillations, and there is an in vitro model in which gamma activity and bursting activity alternates. The alternating activity appears to arise because of use-dependent alterations in synaptic excitation and inhibition.

Keywords:   seizure initiation, synaptic plasticity, VFO

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