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Neuroimaging in Epilepsy$
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Harry Chugani, MD

Print publication date: 2010

Print ISBN-13: 9780195342765

Published to Oxford Scholarship Online: January 2011

DOI: 10.1093/acprof:oso/9780195342765.001.0001

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[11C]Flumazenil Positron Emission Tomography

[11C]Flumazenil Positron Emission Tomography

Chapter:
(p.174) Chapter 11 [11C]Flumazenil Positron Emission Tomography
Source:
Neuroimaging in Epilepsy
Author(s):

Matthias J. Koepp

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195342765.003.0011

This chapter examines the role of Flumazenil (PET) PET in research and clinical practice. FMZ is a good marker for the integrity of GABA-ergic neurotransmission in epilepsy and other diseases. First, methodological aspects of data acquisition and analysis are considered, followed by a summary and meta-analysis of FMZ PET studies in temporal and extra-temporal lobe epilepsies, malformations of cortical development and acquired lesions. The chapter defines the current and future clinical roles of [11C] FMZ PET that it can yield information complementary to structural MR imaging techniques and that this will lead to its use primarily in the presurgical evaluation of patients in whom the epileptogenic area is difficult to define by other means.

Keywords:   flumazenil, GABAA, benzodiazepine, MRI, hippocampal sclerosis

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