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Neuroimaging in Epilepsy$
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Harry Chugani, MD

Print publication date: 2010

Print ISBN-13: 9780195342765

Published to Oxford Scholarship Online: January 2011

DOI: 10.1093/acprof:oso/9780195342765.001.0001

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Positron Emission Tomography: Brain Glucose Metabolism in Pediatric Epilepsy Syndromes

Positron Emission Tomography: Brain Glucose Metabolism in Pediatric Epilepsy Syndromes

Chapter:
(p.156) Chapter 10 Positron Emission Tomography: Brain Glucose Metabolism in Pediatric Epilepsy Syndromes
Source:
Neuroimaging in Epilepsy
Author(s):

Aimee F. Luat

Harry T. Chugani

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195342765.003.0010

The advent of positron emission tomography (PET) scanning using 2-deoxy-2-[18F] fluoro-D-glucose (FDG) has significantly improved our understanding of the pathomechanisms of different pediatric epilepsy syndromes. Furthermore, it has dramatically altered our management approach of certain intractable epilepsy syndromes, such as infantile spasms. Glucose metabolism PET scanning has assumed an important role not only in the identification and localization of epileptogenic cortex, but also in assessing the functional integrity of the entire cerebral hemisphere, thereby providing useful diagnostic and prognostic information, including the suggestion of underlying neurometabolic or neurogenetic disorders which may preclude epilepsy surgery. In certain progressive epilepsy syndromes like Rasmussen encephalitis and Sturge-Weber syndrome, PET scanning also may be used to assess disease progression. In this chapter, we discuss the relevant role of brain glucose metabolism PET in understanding the pathogenesis of pediatric epilepsy syndromes with regard to diagnosis and treatment.

Keywords:   pediatric epilepsy, epilepsy syndromes, brain glucose PET scanning, intractable epilepsy, epilepsy surgery

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